Inmaculada Vivó Sesé, Mª Dolores Plá Miralles, Carolina Carbonell Ripoll, Patricia Ricarte Amorós, José Manuel López Cacho, Gabriella Russo, Paloma Ramírez, Adolfina Ruiz Martínez, Fernando Martínez-Martínez. ‘Estudio de eficacia del producto factor de crecimiento epidérmico + ácido hialurónico fórmula. Study of the efficacy of epidermal growth factor + hyaluronic acid formulated product, Actualidad Médica, Revista nº 795, 2015.

Fabi S, Sundaram H. The potential of topical and injectable growth factors and cytokines for skin rejuvenation. Facial Plast Surg. 2014 Apr; 30(2): 157-71.

Mehta RC, Fitzpatrick RE. Endogenous growth factors as cosmeceuticals. Dermatol Ther. 2007 Sep-Oct;20(5):350-9.

Sundaram H, Mehta RC, Norine JA, Kircik L, Cook-Bolden FE, Atkin DH, Werschler PW, Fitzpatrick RE. Topically applied physiologically balanced growth factors: a new paradigm of skin rejuvenation. J Drugs Dermatol. 2009 May; 8(5 Suppl Skin Rejuenation): 4-13.

Schouest JM, Luu TK, Moy RL. Improved texture and appearance of human facial skin after daily topical application of barley produced, synthetic, human-like epidermal growth factor (EGF) serum. J Drugs Dermatol. 2012 May; 11(5):613-20.

Michael H. Gold MD, Mitchel P. Goldman MD, Julie Biron. Efficacy of Novel Skin Cream Containing Mixture of Human Growth Factors and Cytokines for Skin Rejuvenation. Journal of Drugs in Dermatology 2007; 6 (2):197-202.

Gold MH, Goldman MP, Biron J. Efficacy of novel skin cream containing mixture of human growth factors and cytokines for skin rejuvenation. J Drugs Dermatol. 2007 Feb; 6(2):197-201.

Sundaram H, Mehta RC, Norine JA, Kircik L, Cook-Bolden FE, Atkin DH, Werschler PW, Fitzpatrick RE. Topically applied physiologically balanced growth factors: a new paradigm of skin rejuvenation. J Drugs Dermatol. 2009 May; 8(5 Suppl Skin Rejuenation):4-13.

Michael H. Gold, Md; Bruce E. Katz, Md; Joel L. Cohen, Md; Julie Biron, Human Growth Factor Cream and Hyaluronic Acid Serum in Conjunction with Micro Laser Peel An Efficient Regimen for Skin Rejuvenation. J Clin Aesthet Dermatol. 2010 Dec;3(12):37-42.


Yu, A. , Takeda, A. , Kumazawa, K. , Miyoshi, H. , Kuroyanagi, M. , Yoshitake, T. , Uchinuma, E. , Suzuki, R. and Kuroyanagi, Y. (2015) Preliminary Clinical Study Using a Novel Wound Dressing Composed of Hyaluronic Acid and Collagen Containing EGF. Open Journal of Regenerative Medicine, 4, 6-13.

Mustoe TA, Pierce GF, Morishima C, and Deuel TF: Growth factor induced acceleration of tissue repair through direct and inductive activities. J Clin Invest 87:694–703, 1991.

Yamamoto A, Shimizu N, Kuroyanagi Y. Potential of wound dressing composed of hyaluronic acid containing epidermal growth factor to enhance cytokine production by fibroblasts. J Artif Organs. 2013; 16:489–94.

Shin JU, Kang SW, Jeong JJ, Nam KH, Chung WY, Lee JH. Effect of recombinant human epidermal growth factor on cutaneous scar quality in thyroidectomy patients. J Dermatolog Treat. 2015 Apr; 26(2):159-64.


Martí-Carvajal AJ, Gluud C, Nicola S, Simancas-Racines D, Reveiz L, Oliva P, Cedeño-Taborda J. Growth factors for treating diabetic foot ulcers. Cochrane Database Syst Rev. 2015 Oct 28; 10:CD008548.

Tsang MW, Wong WK, Hung CS, Lai KM, Tang W, Cheung EY, et al. Human epidermal growth factor enhances healing of diabetic foot ulcers. Diabetes Care. 2003; 26:1856–61.

Tiaka EK, Papanas N, Manolakis AC, Georgiadis GS. Epidermal growth factor in the treatment of diabetic foot ulcers: An update. Perspect Vasc Surg Endovasc Ther. 2012; 24:37–44.

Zeng F, Harris RC. Epidermal growth factor, from gene organization to bedside. Seminars in cell & developmental biology. 2014; 0:2-11.

Hernández-Cañete C, Betancourt BY. Management of a hypertensive ulcer with an epidermal growth factor-based formulation. J Wound Care. 2008 Sep; 17(9): 380-2.

Akane Yu, Akira Takeda, Kenichi Kumazawa, Hiroshi Miyoshi, Misato Kuroyanagi, Toshihiro Yoshitake, Eiju Uchinuma, Ryusuke Suzuki, Yoshimitsu Kuroyanagi. Preliminary Clinical Study Using a Novel Wound Dressing Composed of Hyaluronic Acid and Collagen Containing EGF. Open Journal of Regenerative Medicine, 4, 6-13, 2015.


Zhang Y, Wang T, He J, Dong J. Growth factor therapy in patients with partial-thickness burns: a systematic review and meta-analysis. Int Wound J. 2014 Jul 8.

Zheng J, Huang XY, Wei X. The effects of epidermal growth factor on the wound healing of deep partial thickness burn in rats. Zhonghua Shao Shang Za Zhi. 2003; 19:289–92.

Lee JH, Bae IH, Choi JK, Park JW. Evaluation of a highly skin permeable lowmolecular-weight protamine conjugated epidermal growth factor for novel burn wound healing therapy. J Pharm Sci. 2013; 102:4109–20.


Kim YS, Lew DH, Tark KC, Rah DK, Hong JP. Effect of Recombinant Human Epidermal Growth Factor against cutaneous scar formation in murine full-thickness wound healing. Journal of Korean Medical Science. 2010; 25(4): 589-596.


Seidel R, Moy RL. Reduced appearance of under-eye bags with twice-daily application of epidermal growth factor (EGF) serum: a pilot study. J Drugs Dermatol. 2015 Apr; 14(4):405-10.


Seidel R, Moy RL. Improvement in Atrophic Acne Scars Using Topical Synthetic Epidermal Growth Factor (EGF) Serum: A Pilot Study. J Drugs Dermatol. 2015 Sep; 14(9):1005-10.

Kim HK, Yeo IK, Li K, Kim BJ, Kim MN, Hong CK. Topical epidermal growth factor for the improvement of acne lesions: a randomized, double-blinded, placebo-controlled, split-face trial. Int J Dermatol. 2014 Aug;53(8):1031-6.


Treatment of psoriasis through down-regulation of the EGF-receptor with topically-applied EGF. US 20060089304 A1.

Nanney LB, Yates RA, King LE Jr. Modulation of epidermal growth factor receptors in psoriatic lesions during treatment with topical EGF. J Invest Dermatol. 1992 Mar; 98(3):296-301.

Zorzou MP, Stratigos A, Efstathiou E, Bamias A. Exacerbation of psoriasis after treatment with an EGFR tyrosine kinase inhibitor. Acta Derm Venereol. 2004; 84(4): 308-9.

Mascia F, Mariani V, Girolomoni G, Pastore S. Blockade of the EGF Receptor Induces a Deranged Chemokine Expression in Keratinocytes Leading to Enhanced Skin Inflammation. The American Journal of Pathology. 2003; 163(1): 303-312.


Hwang IG, Kang JH, Oh SY, Lee S, Kim SH, Song KH, Son C, Park MJ, Kang MH, Kim HG, Lee J, Park YS, Sun JM, Kim HJ, Kim CK, Yi SY, Jang JS, Park K, Kim HJ. Phase II trial of epidermal growth factor ointment for patients with Erlotinib-related skin effects. Support Care Cancer. 2016 Jan; 24(1):301-9.

Kang H-C, Ahn S-D, Choi D-H, Kang MK, Chung W-K, Wu H-G. The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study. Radiation Oncology Journal. 2014; 32(3):156-162. doi:10.3857/roj.2014.32.3.156.


Recomendaciones de la Sociedad Española de Ginecología y Obstetricia sobre Prevención y Tratamiento de la Atrofia Vaginal. Palacios, S. – Cancelo MJ. -Castro – Branco C. – González, S. “Progresos en Obstetricia y Ginecología”. 2012, 55 (8).

Nelson KG, Takahashi T, Bossert NL, Walmer DK, McLachlan JA. Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 1991;88(1):21-25.

Jokar A, Davari T, Asadi N, Ahmadi F, Foruhari S. Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women: A Randomized Controlled Clinical Trial. International Journal of Community Based Nursing and Midwifery. 2016;4(1):69-78.

Stute P. Is vaginal hyaluronic acid as effective as vaginal estriol for vaginal dryness relief? Arch Gynecol Obstet. 2013 Dec;288(6):1199-201. doi: 10.1007/s00404-013-3068-5.

Bohbot JM, de Belilovsky C, Brami G, Mares P. [Efficacy of a medical device containing liposomal hyaluronic acid against vulvo-vaginal dryness]. [Article in French] Gynecol Obstet Fertil. 2015 Jun;43(6):437-42. Doi: 10.1016/j.gyobfe.2015.04.008. Epub 2015 May 21.

Dinicola S, Pasta V, Costantino D, Guaraldi C, Bizzarri M. Hyaluronic acid and vitamins are effective in reducing vaginal atrophy in women receiving radiotherapy. Minerva Ginecol. 2015 Dec;67(6):523-31.

Hu CH, Xu HY, Zhang DJ, Huang ZF, Zhu WF, Fan SS, Xu J, He JF, Peng JX, Liu CM. [Recombinant human epithelial growth factor accelerates healing of cervical erosion]. [Article in Chinese] Nan Fang Yi Ke Da Xue Xue Bao. 2006 Mar;26(3):342-3, 347.